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便微生物种移植对抑郁症状的有效性影响:基于随机对照试验的元分析

Jiamin Fu^1,2,3, Yuchi Zhang^1,2,3, Jing Gao⁴

¹Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Frontiers in psychiatry

|February 16, 2026

概括

便微生物群移植 (FMT) 对抑郁症没有显著影响. 然而,小组分析表明,对于已确诊的抑郁症患者来说,有潜在的益处,这需要进一步研究.

科学领域:

神经科学是一个神经科学.
胃肠病学胃肠病学
精神病学是一个精神病学.

背景情况:

肠道微生物群是肠-大脑轴的组成部分.
便微生物群移植 (FMT) 对抑郁症的疗效正在研究中.
现有的研究对FMT治疗抑郁症的有效性提出了相互矛盾的证据.

研究的目的:

系统地评估FMT在缓解抑郁症及其症状方面的有效性.
探索人口因素和补充方法对FMT抑郁症结果的影响.

主要方法:

在主要数据库 (PubMed,EMBASE,Web of Science,Cochrane) 进行了系统的文献搜索,截至2025年3月.
使用Revman 5.3软件与标准化平均差异 (SMD) 进行了元分析.
使用标准分级工具评估证据的质量.

主要成果:

七项研究 (235名受试者) 的元分析发现,FMT对抑郁症没有显著的治疗效果 (SMD: -0.10;95% CI: -0.60至0.41;p = 0.71).
亚组分析表明FMT疗效与基线抑郁状态,干预剂量,供体来源,施用途径和饮食习惯之间的潜在相关性.

结论:

目前的证据不足以证实FMT对抑郁症状的疗效.
亚组发现表明,FMT可能在已确诊的抑郁症患者中更有效.
进一步的随机对照试验对于验证 FMT 与抑郁症之间的关联至关重要.

关键词:

抑郁抑郁症抑郁症抑郁症是一种有效性有效性有效性.便微生物群移植胃肠道中的微生物群肠道的微生物群.这是一个元分析.

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