在体外受精后的第二个三个月的妊娠损失:风险因素和风险降低
Sarah Rubin1, Olivia Nussbaum1, Kaleb Noruzi1
1New York Medical College, Valhalla, New York.
F&S reports
|February 16, 2026
概括
在体外受精 (IVF) 后的第二个三个月损失 (STL) 与子宫因素,腺菌症,输卵管不孕症和子宫内痕有关. 两十年来,STL风险的种族和民族差异仍然存在.
科学领域:
- 生殖医学 生殖医学
- 不孕症治疗 不孕症治疗
- 产科 产科 产科 产科 产科
背景情况:
- 20多年来,在体外受精 (IVF) 过程中采用选择性单个胚胎移植可能影响了第二个三个月的损失 (STL) 率.
- 了解试管婴儿后STL不断变化的原因对于改善妊娠结果至关重要.
研究的目的:
- 为了调查在体外受精 (IVF) 后的第二个三个月损失 (STL) 率和潜在原因的变化.
- 将当前的STL率和相关因素与1999-2002年的历史数据进行比较.
主要方法:
- 在2015年至2023年期间通过试管婴儿怀孕的患者进行了一项回顾性队列研究.
- 结果与历史队列进行了比较,并分析了与多胎妊娠,种族,子宫缺陷和输卵管因子不孕症的关联.
主要成果:
- 在971次临床怀孕中,14名患者 (1.4%) 发生了第二个三个月的妊娠损失 (STL).
- 腺肌,子宫内痕和输卵管因子不孕症与增加STL风险显著相关.
- 认同为黑人或西班牙裔的患者显示STL的几率更高,两十年来差异基本保持不变.
结论:
- 在试管婴儿后导致STL的因素包括子宫异常,腺菌症,输卵管不孕症和子宫内痕.
- 在STL中持续存在的种族和民族差异凸显了针对性风险预防策略的需要.
- 需要进一步的研究来开发定制的干预措施,以减少受试管婴儿治疗的风险人群中的STL.
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