打开卵子捐赠的新视野:双卵巢刺激的临床和后勤益处
María Cruz1, Elizabet Henzenn1, Antonio Requena1
1Medical Affairs, IVI Madrid, Madrid, Spain.
F&S reports
|February 16, 2026
概括
在卵子捐赠中,双卵巢刺激 (DuoStim) 提供了后勤效益,在第二次取卵中产生较少的卵子,但保持卵子和胚胎质量. 这种方法提高了循环效率和捐赠者的便利性.
科学领域:
- 生殖医学 生殖医学
- 辅助生殖技术 辅助生殖技术
- 卵巢刺激协议 卵巢刺激协议
背景情况:
- 卵子捐赠计划需要有效和方便的刺激协议.
- 优化卵细胞产量,同时保持质量,对于成功的卵子捐赠至关重要.
研究的目的:
- 评估双卵巢刺激 (DuoStim) 协议在卵子捐赠中的临床和后勤优势.
- 为了比较卵子产量,质量和临床结果,在一个单一周期内的第一和第二次刺激阶段.
主要方法:
- 一项前性观察性研究,涉及60名年龄在18-35岁的健康卵子捐赠者.
- 捐赠者在一个月经周期内经历了两次连续的卵巢刺激和卵细胞检索,使用标准化的协议.
- 测量结果包括卵细胞检索数,爆发率,植入率,临床怀孕和流产率.
主要成果:
- 第一个刺激产生了比第二个 (13.3) 更多的卵细胞 (19.8).
- 玻璃化后的卵细胞存活率 (91.8%与90.5%相比),可使用的胚胎细胞率 (42.8%与49.1%相比),植入率 (69.8%与66.1%相比) 和临床怀孕率 (71.2%与66.7%) 在两种刺激之间是可比的.
- 没有报告过卵巢过度刺激综合征的病例,这表明手术是安全的.
结论:
- 双卵巢刺激 (DuoStim) 是一种安全有效的卵子捐赠方法,可以提高周期效率.
- 虽然第二次刺激产生的卵子较少,但卵子和胚胎的质量都得到了保留.
- 推DuoStim用于优先考虑时间和资源优化的捐助者计划.
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