对于固体瘤的传统中医辅助免疫检查点抑制剂治疗的研究进展
Zhipeng Liu1, Yijie Xie1, Yi He1
1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Frontiers in immunology
|February 16, 2026
概括
传统中国医学 (TCM) 显示出增强固体瘤免疫检查点抑制剂 (ICI) 的潜力. 将TCM与ICI结合起来可以提高癌症治疗的疗效并减少癌症治疗中的不良事件.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 综合医学是一个整体的医学.
背景情况:
- 免疫检查点抑制剂 (ICI) 在癌症治疗中表现有前途,但由于瘤的微环境,在固体瘤中面临局限性,导致低反应率和耐药性.
- 与免疫相关的不良事件 (irAEs) 在ICI治疗中很常见,限制了它们的广泛临床使用.
- 对于增强ICI抗瘤效果和提高安全性概况的策略有着至关重要的需要.
研究的目的:
- 系统地审查当前传统中医 (TCM) 和ICI在固体瘤的联合使用方面的进展.
- 探索TCM在克服ICI相关局限性的潜力.
- 为将TCM纳入未来的癌症治疗策略提供新的视角.
主要方法:
- 对目前关于TCM和ICI结合治疗固体瘤的研究进行系统审查.
- 分析TCM的特征,包括整体监管,多层次,多目标行动和低毒性.
- 评估TCM在解决ICI相关挑战方面的潜力.
主要成果:
- TCM在增强ICI对固体瘤的疗效方面表现出潜力.
- TCM可能有助于减轻与ICI治疗相关的免疫相关不良事件.
- 传统医药的整体和多目标性质为组合策略提供了优势.
结论:
- 将TCM与ICI结合在一起,为改善固体瘤治疗结果提供了一个有希望的策略.
- 传统医疗的独特治疗特性有可能克服ICI目前的局限性.
- 对TCM-ICI组合的进一步研究可能会导致新的,更安全的癌症疗法.
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