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针对多发性骨髓瘤中改善CAR-T细胞控制的量身定制策略

Anna Bielowski1, Teresa Kilian1, Sarah Vera-Cruz1

  • 1Chair for Cellular Immunotherapy, Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.

Frontiers in immunology
|February 16, 2026
PubMed
概括

化学抗原受体 (CAR) T细胞疗法对多发性骨髓瘤具有前景,但需要进行安全控制. 抗体与药物联合体 (ADC) 提供了一种新有效的消除CAR-T细胞的方法,提高了治疗的安全性.

关键词:
针对BCMA的ADC是贝兰他-马福多丁.抗体依赖的细胞细胞毒性抗体药物联合体 (ADCs) 是一种抗体药物联合体.仿制抗原受体 (CAR) T细胞疗法可控制的CAR-T系统多发性骨髓瘤是多发性骨髓瘤的一种.

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