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Updated: Feb 17, 2026

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3-基酸通过ALKBH5/PAX-8/ABCA1通路促进胆固醇的排放并减轻动脉样硬化

Qin-Yi Zhou1, Wang Liu2, Zhen-Wang Zhao3

  • 1Key Laboratory for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, Department of Cardiology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Frontiers in immunology
|February 16, 2026
PubMed
概括

肠道微生物群的代谢物3-基酸 (C18-3OH) 通过调节ALKBH5/PAX-8/ABCA1通路,增强泡细胞中的胆固醇外流. 这一发现为动脉样硬化提供了新的治疗策略.

关键词:
3-基酸是3基酸的一种.ATP绑定磁带传送器 A1 A1 绑定磁带传送器动脉样硬化 动脉样硬化胆固醇排放 排放 排放配对的盒子蛋白质 8 8α-甲酸依赖的二氧化酶 alk B 同类物 5

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