通过捐赠者性别和年龄的死亡率差异在多国肝移植接受者队列中
Lauren T Grinspan1, Xun Zhang2, Mourad Dahhou2
1Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Transplantation direct
|February 16, 2026
概括
捐赠者的年龄显著影响肝移植结果. 年轻的女性捐赠者增加了男性接受者死亡率,而年长的女性捐赠者可能会改善与同龄男性捐赠者相比的生存率.
科学领域:
- 移植免疫学 移植免疫学
- 移植的生存率 移植的生存率
- 器官移植的结果.
背景情况:
- 关于捐赠者的性别对肝移植成功的影响存在相互矛盾的证据.
- 捐赠者的年龄,接受者的性别和移植后的时间可能会改变捐赠者的性别和死亡率的关联.
研究的目的:
- 研究捐赠者的年龄,接受者的性别和移植后的时间如何改变捐赠者的性别和肝移植死亡率之间的关系.
主要方法:
- 分析了198856名已故的捐赠人肝移植 (1988-2019) 来自SRTR和CTS.
- 多变量考克斯模型评估了供体性别与死亡率的关联,包括供体年龄,受体性别和移植后的时间.
- 两个阶段的个人患者数据元分析结合了队列特定结果.
主要成果:
- 在男性接受者中,年轻 (<45岁) 的女性捐赠者比男性捐赠者增加了早期死亡率.
- 在男性接受者中,年龄较大 (≥45岁) 的女性捐赠者与男性捐赠者相比,长期死亡率较低.
- 在移植后的女性接受者中没有观察到显著的捐赠者性别死亡率差异.
结论:
- 捐赠者年龄是捐赠者性别对肝移植死亡率影响的关键修饰因素.
- 年轻的女性捐赠者对男性接受者构成更高的风险,而年长的女性捐赠者可能会带来生存益处.
- 移植存活率似乎是观察到的与供体性别相关的死亡率差异的主要驱动因素.
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