冠状动脉微血管疾病中的心上脂肪组织
Veronika Gašpárková1, Bao Thai Tran2, Petr Ošťádal1
1Department of Cardiology, Motol University Hospital and Second Faculty of Medicine, Charles University, Prague, Czech Republic.
American heart journal plus : cardiology research and practice
|February 16, 2026
概括
心脏周围的脂肪 - - 副心脏脂肪组织 (EAT) 在心血管健康中起着关键作用. 功能障碍的吃有助于心脏病,但针对它的疗法显示出希望.
科学领域:
- 心血管生物学 心血管生物学
- 脂肪组织的新陈代谢
- 医疗成像医学成像
背景情况:
- 副心脏脂肪组织 (EAT) 是一种具有直接心脏连接的代谢活跃的脂肪储存器.
- 从生理学上讲,EAT支持心脏功能;然而,在肥胖和糖尿病等疾病中,它变得有利于炎症和益纤维化.
- 过量和功能障碍的EAT与各种心血管疾病有关,包括冠状动脉疾病和心力衰竭.
研究的目的:
- 审查EAT的生物特征.
- 讨论目前用于EAT评估的成像技术 (心声学,CT,MRI).
- 探索EAT,冠状动脉微血管功能障碍 (CMD) 和心血管病理之间的关联,并总结针对EAT的治疗策略.
主要方法:
- 文献综述专注于EAT生物学,成像和临床影响.
- 综合证据将EAT与心血管疾病病理生理学联系起来.
- 针对EAT的药理和生活方式干预措施的摘要.
主要成果:
- EAT有助于心肌纤维化,腹功能障碍,CMD,并通过炎症和机械途径减少运动能力.
- 像回声心脏图像,CT和MRI这样的成像模式可以检测和量化EAT.
- 包括GLP-1RA,SGLT-2抑制剂,降脂疗法和生活方式改变在内的治疗策略显示出心脏代谢的好处.
结论:
- EAT是心脏代谢性心血管疾病的重要贡献者.
- EAT具有作为成像生物标记物和治疗点的潜力.
- 准EAT为管理心血管疾病提供了一个有希望的途径.
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