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FOXO3上调并激活GSDME,从而触发骨髓瘤细胞灭

Yaner Wang^1,2, Yali Wang^1,3, Yaoli Cui¹

¹Department of Hematology, The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University; Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.

International journal of biological sciences

|February 16, 2026

概括

转录因子FOXO3调节了GSDME,这是多发性骨髓瘤 (MM) 中一个关键的烧灭基因. 激活FOXO3/GSDME通路,可能是用林,为MM提供了一个新的治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

Pyroptosis诱导是多发性骨髓瘤 (MM) 治疗的新策略.
在MM中诱导热的潜在分子标仍然在很大程度上是未知的.

研究的目的:

确定MM中热的关键调节剂.
调查GSDME及其监管机制在MM中的作用.
探索针对已识别的途径的潜在治疗策略.

主要方法:

在MM细胞中的基因表达分析.
识别转录因子结合部位.
西方涂抹测试以评估蛋白质水平.
使用MM模型进行体外和体外研究.
用科里林 (corylin) 治疗,这是一种天然的黄胺.

主要成果:

GSDME,一个 pyroptosis执行器,在MM下调调节,并预测不良预后.
FOXO3 作为 GSDME 的转录因子,对其表达进行上调.
此外,FOXO3还对BNIPL蛋白进行上调,激活Caspase-3和GSDME,诱导热.
在MM中,GSDME和FOXO3都被下调;FOXO3的恢复抑制了瘤的生长.
科里林激活FOXO3和GSDME转录,通过热死表现出抗MM活性.

结论:

FOXO3是MM中GSDME的新型转录因子.
FOXO3/GSDME轴对MM细胞烧灭至关重要.
恢复或激活FOXO3/GSDME通路为MM提供了一个有希望的治疗策略.

关键词:

在FOXO3中使用FOXO3.在GSDME中,GSDME是GSDME.科里林林是指一个的物质.骨髓瘤多样性骨髓瘤多样性热灭症是什么?

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