基于结石的成分分析的代谢洞察:对506名患者的回顾性研究
Sadik Portakal1, Basri Cakiroglu2,3, Bekir Sami Uyanık4
1Family Medicine, Hisar Intercontinental Hospital, Istanbul, TUR.
Cureus
|February 16, 2026
概括
结石成分分析显示,氧化二水合物 (COD) 是最常见的类型. 石头类型与代谢因素和复发有关,指导更好的患者管理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物化学 生物化学
背景情况:
- 石病是一个日益严重的全球健康问题,发病率和复发率很高.
- 了解石材成分对于识别代谢障碍和指导患者管理至关重要.
研究的目的:
- 为了分析结石组成的分布,在一个大型的手术队列.
- 为了研究石头组成,代谢参数和石头复发模式之间的关系.
主要方法:
- 对506名接受手术切除石头的成年患者 (2018-2024) 的回顾性分析.
- 福里埃变换红外光谱 (FTIR) 用于石材组成分析 (氧化单,氧化二,尿酸,混合类型).
- 血清 (,尿酸,葡萄糖) 和24小时尿路 (,氧沙酸,酸盐,尿酸) 参数的评估;第一次发作和复发性结石形成者之间的比较.
主要成果:
- 氧化二 (COD) 是最常见的石头类型 (60.7%),其次是氧化单 (COM) (23.1%).
- 尿酸结石与显著老年患者相关 (p<0.001).
- 在石材成分组之间没有观察到身体质量指数的显著差异.
结论:
- 富里埃变换红外线 (FTIR) 分析石头成分显示了与代谢异常和复发的重要联系.
- 将石材成分数据与全面的代谢评估相结合,可以增强患者的随访和预防策略.
- 由构成导向的解释,而不是独立的工具,支持对结石疾病的知情临床决策.
相关概念视频
01:30Urinary Tract Calculi III: Medical Management
285
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
285
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
455
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
455
01:28Urinary Tract Calculi I: Introduction
587
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
587
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
452
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
452
01:29Urine Studies I: Urinalysis
1.6K
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
1.6K
01:25Urinary Tract Calculi VI: Surgical Management
588
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
588