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Updated: May 6, 2026

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

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在表皮生长因子受体 (EGFR) -突变肺腺癌中获得的CCD6-RET融合后的第一线奥西默蒂尼布:一个病例报告

Ana Raquel S Afonso1, Luisa Nascimento1, Margarida Cruz1

  • 1Department of Pulmonology, Unidade Local de Saúde de Trás-os-Montes e Alto Douro, Vila Real, PRT.

Cureus
|February 16, 2026
PubMed
概括

获得的RET融合可以在非小细胞肺癌 (NSCLC) 中引起对 osimertinib 的耐药性. 分子重新评估对于识别罕见的耐药性机制和指导EGFR突变NSCLC的治疗策略至关重要.

关键词:
获得的电阻 获得的电阻ccdc6-ret 在线阅读egfr - 突变的nsclccc是什么意思奥西米尔丁尼布 (osimertinib) 是一种重组重新安排重新安排.塞尔珀卡提尼布 (selpercatinib) 是一种可以

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Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids08:52

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Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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