扩散型大B细胞淋巴瘤在42岁的女性中呈现单独的壮症:一种罕见的初级脏参与的罕见情况
Meena Ln1, Steve Thomas2, Sri Gayathri Shanmugam3
1General Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Cureus
|February 16, 2026
概括
初级膜扩散性大B细胞淋巴瘤 (DLBCL) 很少见,难以诊断. 这一案例突出显示了孤立的脊髓巨变作为一个关键指标,脊髓切除术被证明是诊断和治疗的有效方法.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 初级膜扩散大B细胞淋巴瘤 (DLBCL) 是一个不常见的实体.
- 由于非特定的临床表现,诊断可能具有挑战性.
研究的目的:
- 报告一个DLBCL病例,仅表现出孤立的脊髓大病.
- 强调脊髓切除术在特定情况下的诊断和治疗作用.
主要方法:
- 一个42岁的女性病例报告,她患有孤立的大病.
- 诊断工作包括成像 (超声波,CT,PET-CT) 和骨髓活检.
- 组织病理学和免疫组织化学证实DLBCL,非生殖中心亚型.
- 在脊髓切除术后,治疗包括R-CHOP化疗.
主要成果:
- 患者呈现出大规模的脊髓壮大,腹部张张和体重减轻.
- 图像检测显示了孤立的脏代谢活动;骨髓没有显著的.
- 切除术证实DLBCL;免疫组织化学显示了特定标记物和高的Ki-67指数.
- 化疗后的PET-CT显示了完全的代谢反应,没有复发.
结论:
- 孤立的大可能是DLBCL的唯一表现特征.
- 脊髓切除术作为一种有价值的诊断和治疗工具,用于怀疑脊髓淋巴瘤的选定患者.
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