表面麻醉剂对舌头感官功能的影响
Mami Takemori1, Mika Honda-Sakaki2, Wakana Nakamoto3
1Department of Anesthesiology, Nihon University School of Dentistry at Matsudo, Chiba, JPN.
Cureus
|February 16, 2026
概括
班佐卡因 (BEN) 和利多卡因化物 (LDCA) 在舌尖上表现出类似的麻醉作用. 这项研究比较了它们对感觉功能的影响,表明BEN可能是治疗燃烧口腔综合征 (BMS) 的可行选择.
科学领域:
- 口服药是一种口服药.
- 药理学 药理学是指药理学的学科.
- 感官科学是一种感官科学.
背景情况:
- 燃烧口腔综合征 (BMS) 是一种经常用利多卡因化物 (LDCA) 治疗的疾病.
- 佐卡因 (BEN) 对BMS治疗和检查的疗效需要进一步研究.
- 量化感官测试用于评估局部麻醉剂对口腔感官感知的影响.
研究的目的:
- 评估本佐卡因 (BEN) 作为治疗口腔炎综合征 (BMS) 的潜力.
- 为了比较本佐卡因 (BEN) 和利多卡因化物 (LDCA) 对舌尖感官功能的麻醉作用.
- 研究这些麻醉剂对机械检测值 (MDT),机械疼痛值 (MPT) 和数值评分表 (NRS) 评分的影响.
主要方法:
- 这是一项单盲随机交叉研究,涉及30名健康女性.
- 应用2%的LDCA,20%的BEN,和一个瓦塞林控制的舌尖在三个单独的天.
- 在基线和应用后的多个时间点测量MDT,MPT和NRS.
主要成果:
- 与基线值相比,2%的LDCA和20%的BEN都显著增加了MDT,应用后立即和长达15分钟.
- 对于这两种麻醉剂,MPT的显著增加被观察到,LDCA显示效果长达30分钟,BEN长达15分钟.
- 在测量期或测试麻醉剂之间没有发现NRS得分的显著差异.
结论:
- 2%的LDCA和20%的BEN在健康的舌尖的感官功能上表现出类似的麻醉作用.
- 可因 (BEN) 可能作为一种可行的替代或辅助治疗,用于诸如口腔炎综合征 (BMS) 等疾病.
- 需要进一步的研究来证实BMS患者的这些发现.
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