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在印度成年人中,与血相比,在干血斑中量化25-氧维生素D₃

Ashwini V Shete¹, Jyoti Sawant¹, Rajani Bagul¹

¹ICMR National AIDS Research Institute, Pune, Maharashtra, India.

|February 16, 2026

概括

干血斑 (DBS) 是在大型研究中评估维生素D状况的经济有效方法. 这项研究发现,在老年印度成年人中,DBS和血中测量的维生素D水平之间存在很好的一致性.

科学领域:

老年学是一门学科.
营养科学营养科学
生物化学生物化学

背景情况:

维生素D对于老年人的身体和认知健康至关重要.
通过血清/血进行标准的维生素D评估对于大型流行病学研究来说是昂贵的.
干血斑 (DBS) 是维生素D评估的潜在替代品.

研究的目的:

为了评估25-基维生素D3 (25(OH) D3) 量化使用DBS与血相比的一致性.
确定在涉及老年印度成年人的流行病学研究中使用DBS评估维生素D状态的可行性.

主要方法:

在浦那的58名印度成年人 (年龄>45岁) 收集了配对的血和DBS样本.
液体染色学-并联质谱学 (LC-MS/MS) 用于25(OH) D3的量化.
使用Pearson的相关性和中位数度的比较来评估协议.

主要成果:

在血和DBS 25(OH) D3水平之间观察到很高的相关性 (皮尔森r=0.976).
中位数的25(OH) D3度为14.6 ng/mL (血) 和12.8 ng/mL (DBS).
平均而言,DBS测量比血测量低6%.

结论:

从DBS和血中得到的25[OH]D3量化结果之间存在很好的一致性.
在印度的大规模流行病学研究中,DBS是一种可行的,可能更具成本效益的维生素D评估方法.

关键词:

酸二醇是一种酸.干燥血液点检测测试干燥血液点检测微量营养素微量营养素微量营养素验证研究验证研究维生素D 维生素D是一种维生素.

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