病例报告:散布原发性肺癌呈慢性肠病变的狗
Yuvani Bandara1, Sarah B Shropshire1, Kelly Hughes1
1Colorado State University, Fort Collins, CO, United States.
Frontiers in veterinary science
|February 16, 2026
概括
这项研究报告了一种罕见的原发性肺癌 (PPC) 病例,该病例发生在一只最初出现胃肠道症状的狗身上. 经过广泛的诊断评估,犬癌最终被诊断为传播PPC.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 在瘤学瘤学.
- 比较病理学比较病理学
背景情况:
- 对治疗无反应的肠道病变可能表明潜在的瘤.
- 胃肠道症状在狗中很常见,但可以掩盖其他严重的疾病.
- 初级肺癌 (PPC) 在狗中很少见,并且经常出现呼吸道症状.
研究的目的:
- 报告一只狗患有扩散性原发性肺癌 (PPC) 的独特病例.
- 为了突出PPC出现胃肠道症状的诊断挑战.
- 强调耐火性肠道病变的彻底诊断工作的重要性.
主要方法:
- 一个10岁的混血犬的临床病例介绍.
- 诊断程序包括血液检查,腹部超声波,胃肠内镜,活检,胸部放射和细胞学.
- 使用甲状腺转录因子-1 (TTF-1) 进行免疫组织化学检查.
主要成果:
- 最初的诊断显示了淋巴透的十二指甲状腺癌,怀疑是新生的初级十二指甲状腺癌.
- 后来,这只狗患上了瘤性腹膜输液,失去蛋白质的肠病,以及肺结节.
- 尸体解剖证实了扩散的PPC与新发性栓塞和脂质质淋巴炎;TTF-1染色证实了肺部起源.
结论:
- 在狗中,散播性原发性肺癌可能主要表现为胃肠道症状.
- 这一案例强调了需要考虑肺部瘤的胸外表现.
- 这是首次报告的犬类PPC病例,最初出现肠病变.
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