可持续的AGP替代品:对非抗生素生长调节剂标准化,协同配方和环境安全的系统方法
Manzar Abbas1,2, Ghulam Abbas3, Fatima4
1Inner Mongolia Saikexing Institute of Breeding and Reproductive Biotechnology in Domestic Animal, Hohhot, China.
Frontiers in veterinary science
|February 16, 2026
概括
消费者对无抗生素牲畜的需求正在增加. 本综述探讨了非抗生素策略,如植物性食品添加剂 (PFAs),作为促进动物健康和减少抗菌素耐药性的可持续替代品.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 食品安全 食品安全
背景情况:
- 消费者对无抗生素牲畜产品 (RWA/NAE) 的需求不断增长.
- 与抗生素增长促进剂 (AGP) 相关的抗菌素耐药性 (AMR) 危机日益严重.
- 对料抗生素的严格监管限制需要可持续的替代品.
研究的目的:
- 审查和评估用于提高畜牧业生产的非抗生素策略.
- 建立基于AGP机制 (肠道微生物群,免疫调节) 的替代疗效基准.
- 确定符合全球禁止料抗生素的首选替代品.
主要方法:
- 对当前的抗生素替代品进行批判性评估:益生菌,益生菌,共生菌,有机酸,酶和植物性食品添加剂 (PFAs).
- 评估新兴技术:抗微生物 (AMP),IgY,菌体,基因组药物,粘土和微量矿物质.
- 突出商业上已批准的例子,例如,用于控制沙门氏菌的菌体.
主要成果:
- 植物性食品添加剂 (PFAs) 由于其抗微生物,抗氧化剂和肠道健康特性,以及成本效益和可扩展性,被确定为首选的替代品.
- 在改善料效率,生长性能和动物健康方面证明了替代品的成功.
- 对于许多替代品的一致性,生物可用性和监管批准,仍然存在挑战.
结论:
- 自然和先进的替代品的战略组合,特别是优化的PFA配方,为无抗生素的畜牧业提供了一条可行的途径.
- 这些替代方案对于减轻AMR风险和确保未来的粮食安全至关重要.
- 需要进一步的研究和开发来克服现有的挑战,并促进广泛采用.
更多相关视频
07:42Deferred Growth Inhibition Assay to Quantify the Effect of Bacteria-derived Antimicrobials on Competition
Published on: September 3, 2016
15.5K
11:31Establishment of a High-throughput Setup for Screening Small Molecules That Modulate c-di-GMP Signaling in Pseudomonas aeruginosa
Published on: June 30, 2016
9.2K
相关概念视频
01:28Biological Methods for Microbial Control
918
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
918
01:29Methods for Controlling Microbial Growth
1.8K
Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
1.8K
01:28Global Regulatory Systems
745
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
745
01:22Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
214
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
214
00:57Antibiotic Selection
60.3K
Overview
60.3K
01:28Gene Regulation in Microbial Communities: Quorum Sensing
714
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
714