Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.8K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

681
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
681
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

18.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.6K
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

656
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
656
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.1K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Understanding the role of hypertension in stroke outcomes using Bayesian analysis.

Scientific reports·2025
Same author

An intelligent YOLO and CNN-BiGRU framework for road infrastructure based anomaly assessment.

Scientific reports·2025
Same author

Study of the Patterns of DNA Methylation in Human Cells Through the Prism of Intra-Strand DNA Symmetry.

International journal of molecular sciences·2025
Same author

Behind the care: emotional struggles, burnout, and denial in kazakhstan's professional palliative care workforce.

BMC palliative care·2025
Same author

The Regional Burden of Parkinson's Disease in Kazakhstan 2014-2021: Insights From National Health Data.

Parkinson's disease·2025
Same author

Predicting Intensive Care Unit Admission in COVID-19-Infected Pregnant Women Using Machine Learning.

Journal of clinical medicine·2025

相关实验视频

Updated: Feb 17, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

8.2K

使用机器学习的基于SNP的精神分裂症预测.

Zamart Ramazanova1,2, Bakhyt Matkarimov2,3, Sheida Nabavi4

  • 1Department of Electrical and Computer Engineering, School of Engineering and Digital Sciences, Nazarbayev University, 53 Kabanbay Batyr Avenue, Astana, 010000, Kazakhstan.

Bioinformatics advances
|February 16, 2026
PubMed
概括
此摘要是机器生成的。

这项研究使用遗传数据 (SNP) 预测精神分裂症风险. 机器学习模型显示出高精度,特别是在非裔美国女性和欧洲裔美国男性中,这表明了潜在的临床实用性.

更多相关视频

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.3K
Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.6K

相关实验视频

Last Updated: Feb 17, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

8.2K
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.3K
Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.6K

科学领域:

  • 精神病学遗传学 精神病学遗传学
  • 计算生物学 计算生物学
  • 人口遗传学 人口遗传学

背景情况:

  • 精神分裂症影响全球约0.32%,以认知和情绪缺陷为特征.
  • 了解精神分裂症的遗传结构对于识别致病变体至关重要.
  • 单核酸多态 (SNP) 是复杂疾病的关键遗传标记.

研究的目的:

  • 评估使用个人SNP资料预测精神分裂症的可行性.
  • 开发针对精神分裂症的特定种族和性别的预测模型.
  • 为了确定与精神分裂症风险显著相关的SNP.

主要方法:

  • 利用来自4693名参与者 (欧洲裔美国人和非洲裔美国人) 的全基因组关联 (GWA) 数据.
  • 采用机器学习技术用于基于SNP的预测模型构建.
  • 应用特征选择,关联分析和分层的五倍交叉验证.

主要成果:

  • 开发了具有不同准确度的特定种族和性别模型 (EA-F,EA-M,AA-F,AA-M).
  • 获得的分类精度 (AUC) 为75.1% (EA-F),65.4% (EA-M),68.6% (AA-F) 和73.9% (AA-M).
  • 对AA-F,EA-F和EA-M的模型表现出高灵敏度 (>70%),表明作为辅助临床工具的潜力.

结论:

  • 基于SNP的预测模型显示了评估精神分裂症风险的可行性.
  • 特定于种族和性别的模型提供了量身定制的风险评估潜力.
  • 高灵敏度模型可以帮助早期识别特定人群的风险.