从知识景观到网络机制:绘制ALS中受调节的细胞死亡途径
Jingxuan Zhang1, Zilin Zhao2, Tianyue Xiang2
1First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, China.
Frontiers in aging neuroscience
|February 16, 2026
概括
关于肌缩侧面硬化症 (ALS) 和调控细胞死亡 (RCD) 的研究正在扩大,揭示了相互连接的途径. 生物信息学和文献计量学将免疫代谢信号作为一个关键的融合点,突出强调ferroptosis,炎症和自为潜在的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 遗传学 是一个遗传学.
背景情况:
- 肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病.
- 调节细胞死亡 (RCD) 途径越来越多地与ALS病变发生有关.
- 了解ALS和RCD之间的相互作用对于确定治疗点至关重要.
研究的目的:
- 绘制关于肌缩侧面硬化症 (ALS) 和调控细胞死亡 (RCD) 的研究格局.
- 将图书统计学趋势与生物信息学数据整合起来,以确定ALS-RCD研究中的融合机制和可操作的目标.
主要方法:
- 使用CiteSpace,VOSviewer和bibliometrix对6272篇出版物 (2005-2024) 的图书统计分析.
- 生物信息学分析交叉ALS相关基因与亡,铁亡和热亡基因组.
- 构建蛋白质与蛋白质相互作用 (PPI) 网络,确定核心模块,枢纽基因和丰富分析 (GO/KEGG).
主要成果:
- 2015年以后,ALS-RCD研究的出版和引用率显著增加,全球贡献越来越多.
- 关键词演变表明,在持续的ALS主题旁边,人们正在向多途径RCD转变,包括ferroptosis, pyroptosis和autophagy.
- 生物信息学揭示了ALS和RCD之间的遗传重叠,确定TP53,AKT1,STAT3和MYC作为关键的枢纽基因,并涉及脂质,FoxO和HIF-1通路.
结论:
- ALS和RCD的研究正集中在相互连接的细胞死亡程序上.
- 综合证据支持一种免疫代谢融合,涉及ALS中的ferroptosis,炎症和自信号.
- 这项研究提供了一套专注的候选途径和枢纽目标,用于进一步的机制验证和治疗翻译.
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