昼夜节律通过肠道微生物群依赖的Th17细胞扩张来调节骨质细胞循环
Shuo Ni1, Weicong Fu2, Lizong Zhang3
1Department of Orthopedic Surgery and Institute of Microsurgery on Extremities,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Current research in microbial sciences
|February 16, 2026
概括
通过食来破坏昼夜节律,可以通过改变肠道细菌和免疫细胞来引起骨质损失. 这项研究揭示了一个肠道微生物群-Th17-骨形通路,与昼夜干扰和骨稳定有关.
科学领域:
- 时间生物学 时间生物学
- 免疫学 免疫学 免疫学
- 骨生物学 骨生物学 骨生物学
- 微生物组研究 微生物组研究
背景情况:
- 昼夜节律对哺乳动物生理学至关重要,维持恒常状态.
- 扰乱昼夜节律会对免疫和代谢功能产生负面影响,增加疾病风险.
- 了解骨健康的昼夜调节是至关重要的.
研究的目的:
- 为了研究昼夜节律扰乱对骨健康的影响.
- 为了确定连接昼夜失调,肠道微生物群和骨质损失的机制.
- 探索免疫细胞和骨质细胞前体在这个过程中的作用.
主要方法:
- 在雄性小鼠中利用长期休息阶段的时间限制养 (TRF) 来破坏昼夜节律.
- 通过TRF诱导的肠道微生物群失调.
- 从昼夜失调的捐赠者进行便微生物群移植 (FMT) 到无细菌的接受者.
- 分析了RANKL-RANK-OPG信号通路和骨质细胞前体 (骨型) 融合.
主要成果:
- 在雄性小鼠中,长期的TRF诱导了显著的骨质损失和肠道微生物群失生.
- 来自昼夜不整齐的捐赠者的FMT增加了接受者的Th17细胞群.
- 增加的Th17细胞通过RANKL-RANK-OPG通路促进了骨型融合到成熟的骨质细胞.
结论:
- 一个新的肠道微生物群-Th17-骨型轴介导昼夜干扰诱导的骨损失.
- 昼夜节律在通过这个轴调节骨平衡中起着至关重要的作用.
- 这项研究揭示了一个新的机制,将昼夜生物与骨健康联系起来.
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