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血TMAO和中风的剂量反应元分析:验证的线性风险值为3.0μmol/L

Jiakai Zhang¹, Tao Yu¹, Lefang Liu¹

¹Multi-Specialty Ward, Maternal and Child Health Care Hospital of Dong'e, Liaocheng, Shandong, China.

Frontiers in neurology

|February 16, 2026

概括

三甲基胺N氧化物 (TMAO) 与中风风险增加有关. 对TMAO的值为3.0μmol/L表明风险明显更高,需要采取预防策略.

科学领域:

心血管研究研究心血管研究
代谢学代谢学代谢学
神经学神经学

背景情况:

脑卒中,特别是缺血性脑卒中,是全球死亡和残疾的主要原因之一.
可修改的风险因素为预防中风提供了机会.
三甲基胺N氧化物 (TMAO) 是肠道细菌的代谢物,与血管损伤和中风风险增加有关.

研究的目的:

量化TMAO和中风风险之间的持续剂量-反应关系.
确定TMAO的特定,临床可操作的风险值.
以TMAO水平为基础,为中风的预防策略提供信息.

主要方法:

一个符合PRISMA的11项观察性研究的元分析 (n=7,556).
包括TMAO水平的整体元分析和使用受限立方线的剂量反应元分析.
评估异质性,敏感性和出版偏差.

主要成果:

与对照组相比,中风患者的TMAO水平显著更高 (SMD=0.55).
每增加1μmol/L的TMAO与中风风险上升8.9%相关 (OR=1.089).
一个TMAO水平>3.0μmol/L被确定为一个显著的风险值 (OR>1).

结论:

TMAO显示了与中风风险的线性,剂量依赖的关联.
一个TMAO水平≥3.0μmol/L表示临床干预的临界值.
确定这一门有助于制定针对性预防中风的预防策略.

关键词:

脑血管疾病的意外发生.剂量反应元分析.观察性研究是一种观察性研究.一次性中风中风中风中风中风三甲基胺N-氧化物

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