活跃癌症和急性缺血性中风患者的组织因子活性和1年死亡率:SCAN研究的发现
Yasufumi Gon1,2, Tomohiro Kawano1, Takaya Kitano1
1Department of Neurology, Graduate School of Medicine, The University of Osaka, Japan.
Research and practice in thrombosis and haemostasis
|February 16, 2026
概括
提高组织因子 (TF) 活性与患有活跃癌症和急性缺血性中风的患者的死亡率较高有关. 这一发现表明,TF活性可能是这个患者组的有价值的预后生物标志物.
科学领域:
- 心血管研究研究心血管研究
- 在瘤学瘤学.
- 神经学 神经学
背景情况:
- 组织因子 (TF) 启动凝血,并与癌症相关的血栓形成有关.
- 在患有活跃癌症 (AC) 和急性缺血性中风 (AIS) 的患者中,TF的预后价值尚未确定.
研究的目的:
- 调查血TF活性与AC和AIS患者的结果之间的关联.
主要方法:
- 在日本进行的前性多中心观测研究 (SCAN研究).
- 使用染色体检测测量血TF活性.
- 使用卡普兰-梅尔和考克斯比例危险模型对1年死亡率的分析.
主要成果:
- 高TF活性与远程转移和D-二次体水平的增加有关.
- 具有高TF活性的患者表现出显著更高的一年死亡率 (日志等级测试,P < .001).
- 高TF活动独立预测死亡率增加 (HR,3.03;P = .011).
结论:
- 升高的TF活性是AC和AIS患者1年死亡率的独立预测因素.
- 血TF活性可以作为这个人群的预后生物标志物.
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