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Chronic Salmonella Infected Mouse Model
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与使用非抗生素料添加剂相关的肠道形态变化发生在患有沙门氏菌 (Salmonella Enteritidis) 的 brojler中
Laelia Reginae do Monte Pessoa Felix1, Alexandre Lemos de Barros Moreira2, Maylane Rayane Brito Dos Santos1
1Department of Animal Science (DZ), College of Agricultural Sciences (CCA), Federal University of Paraíba (UFPB), Areia-PB 58397-000, Brazil.
Journal of animal science and technology
|February 16, 2026
概括
非抗生素料添加剂,包括一个后生物 (PFC) 和一个植物生物 (SAN),改善了肠道健康和体重增加在肉小挑战的沙门氏菌 (SE). 这些添加剂为传统增长促进剂提供了有希望的替代品.
科学领域:
- 动物科学动物科学
- 肠道健康 肠道健康
- 禽类的营养 养
背景情况:
- 抗微生物生长促进剂正在逐步淘汰,因此需要替代品来改善肉的健康状况.
- 非抗生素料添加剂在肉幼早期感染期间对肠道健康的影响尚不清楚.
- 沙门氏菌 (SE) 感染显著影响肉肠道形态和生长性能.
研究的目的:
- 为了评估后生物 (PFC) 和血红素基植物生物 (SAN) 作为非抗生素料添加剂的有效性.
- 为了研究PFC和SAN对肠道形态和肉小的体重增加的影响,这些小受到沙门氏菌 (SE) 的挑战.
- 了解这些添加剂作为家禽抗菌生长促进剂的替代品的潜力.
主要方法:
- 采用了2x3的因数设计,使用了144只肉,包括SE挑战和非挑战组.
- 小被食控制饮食 (DCO),后生物 (PFC) 或基于血红素的化合物 (SAN).
- 肠道形态 (状体高度,密室深度,状体:密室比率,自身膜厚度) 和SE计数在注射后的3,7和14天被评估;体重增加在14天后被测量.
主要成果:
- 后生物 (PFC) 补充剂在注射后3天和7天减少了沙门氏菌的数量.
- 受到SE挑战的小在肠道形态上表现出负面的变化 (增加密室深度,膜自身厚度;减少:密室比率).
- 与对照饮食相比,PFC和SAN都改善了肠道形态 (增加了小的高度,小:密码比,小面积;减少了自身层的厚度).
- 基于血红素的植物生物 (SAN) 补充剂在化后14天增加了体重和体重增加.
结论:
- 后生菌 (PFC) 和血红素基植物生物 (SAN) 补充剂在受到沙门氏菌感染的肉小中积极调节了肠道形态.
- 这些非抗生素料添加剂在减轻早期SE感染的不良影响方面具有潜力.
- PFC和SAN代表了抗微生物生长促进剂的可行替代品,改善了 brojler的肠道健康和生长性能.
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