JGR-NMF:用于空间域识别的联合图形规则化的非负矩阵分解
Juan Liang1, Jiuxi Huang2, Chenxi Xi2
1School of Computer Science and Technology, Henan Institute of Technology, Xinxiang, Henan, China.
PeerJ
|February 16, 2026
概括
我们开发了联合图形调节非负矩阵因子化 (JGR-NMF) 以准确地识别组织中的空间域. 这种方法通过优化邻域大小和整合图形结构来增强空间转录学分析.
科学领域:
- 计算生物学 计算生物学
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 空间转录学为细胞分布和组织架构提供了新的见解.
- 准确识别空间域对于理解组织功能至关重要.
研究的目的:
- 为改进空间域识别引入联合图形规则化的非负矩阵因数分解 (JGR-NMF).
- 为了提高空间转录学数据分析的准确性和稳定性.
主要方法:
- 开发了一种使用n-次权转换的自适应邻近图形构建策略.
- 在JGR-NMF框架内将自适应的kNN图形与空间邻矩阵集成.
主要成果:
- 在乳腺癌,小鼠脏和小鼠胚胎数据集方面,JGR-NMF显著超过了五种最先进的方法.
- 废除研究证实了图形规律化对性能提升的重要性.
结论:
- JGR-NMF为空间域识别提供了强大而准确的方法.
- 适应式图形构造和图形规则化是改善空间转录学分析的关键组成部分.
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