结核病与不受控制的血红蛋白A1c水平在1型糖尿病儿童患者中之间的关联
Amy Lin1, Michelle Jankowski1, Shirley Qu2
1Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA, oakland.edu.
Pediatric diabetes
|February 16, 2026
概括
乳病 (CD) 在患有1型糖尿病 (T1D) 的儿童中显著恶化血糖控制. 这表明需要对这些患者进行更密切的监测和定制干预措施.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 胃肠病学 胃肠病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 结核病 (CD) 影响了大约6%的1型糖尿病 (T1D) 患者.
- 由于CD和T1D的同时发生,在管理血糖控制方面存在挑战,因为饮食要求相互矛盾.
- 以前对CD对儿科患者血红蛋白A1c (HbA1c) 水平的影响的研究已经产生了不一致的结果.
研究的目的:
- 为了评估患有1型糖尿病的儿科患者中乳病和血糖控制之间的关联.
- 确定是否存在乳病独立影响该队列中的血红蛋白A1c水平.
主要方法:
- 在2012年至2023年期间诊断出T1D的儿科患者 (18岁以下) 进行了回顾性图表审查.
- 患者使用ICD-10代码进行鉴定,并根据乳病状况和血糖控制 (HbA1c <7% vs. ≥7%) 分类.
- 统计分析包括奇平方/费舍尔精确测试,威尔科克森测试和物流回归来评估关联.
主要成果:
- 在2,203名儿科T1D患者中,101名 (4.6%) 患有CD.
- 患有T1D和CD的患者在诊断时更年轻 (中位数为9岁对12岁),患有失控糖尿病的比例更高 (89.1%对73.8%).
- 结核病与失控的血糖控制独立相关 (调整后OR:2.59;95%CI:1.37至4.90).
结论:
- 结核病与1型糖尿病儿科患者的血糖控制较差有显著联系.
- 这些发现强调了对患有CD的儿科T1D患者进行警监测和个性化干预的重要性.
- 针对性饮食咨询和管理策略对于这种高风险人群至关重要.
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