作为急性胰腺炎严重程度和死亡率的预测因素的入院高酸血症:一项1000名患者的队列研究
Yavuz Özden1, Nuh Mehmet Buyukberber2
1Department of Gastroenterology, Kayseri City Hospital, University of Health Sciences, Kayseri 38080, Türkiye. yavuzozden@gmail.com.
World journal of gastrointestinal surgery
|February 16, 2026
概括
住院高血是严重急性胰腺炎 (AP) 和早期死亡的简单预测因素. 这一发现支持使用血清酸盐水平用于AP患者的快速风险分层.
科学领域:
- 胃肠病学 胃肠病学
- 内部医学 内部医学
- 临床化学 临床化学
背景情况:
- 急性胰腺炎 (AP) 可以发展为严重的疾病,导致严重的发病率和死亡率.
- 目前的AP风险分层方法复杂,需要推迟评估.
研究的目的:
- 为了确定是否在入院时血清酸盐水平可以预测AP的严重程度和短期结果.
- 评估血清酸盐作为AP风险分层的早期生物标志物.
主要方法:
- 对1000名AP患者的回顾性分析.
- 摄入血清酸盐的分类:低酸血症 (<2.5 mg/dL),正常酸血症 (2.5-4.5 mg/dL) 和高酸血症 (>4.5 mg/dL).
- 评估结果包括严重的AP (SAP),胰腺亡,ICU入院和30天死亡率;使用多变量后勤回归.
主要成果:
- 与正常酸性血症相比,高酸性血症与SAP (60%对20%),胰腺亡 (50%对10%) 和ICU入院 (70%对15%) 的发生率明显高.
- 在患有高酸血症的患者中,三十天死亡率明显高 (25%与3%相比).
- 住院高酸性血症独立预测了30天死亡率 (调整后OR为5.8),即使调整了肌素和急性损伤 (AKI).
结论:
- 入院高酸血是严重AP,胰腺亡,ICU入院和早期死亡的独立预测因素.
- 血清酸盐水平是AP早期风险分层的简单,廉价的生物标志物.
- 这一发现可以帮助临床医生在入院后立即识别高风险的AP患者.
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