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自闭症谱系障碍患者的比喻语言理解的大脑激活模式:一个激活可能性估计元分析

Lulu Cheng¹, Jianxin Zhang¹, Haoran Mao¹

¹School of Foreign Studies, China University of Petroleum (East China), Qingdao, China.

Frontiers in neuroscience

|February 16, 2026

概括

患有自闭症谱系障碍 (ASD) 的人在理解比喻语言时,表现出左上旋和中旋中脑活性减少. 这可能解释了ASD的务实语言困难.

科学领域:

神经科学是一个神经科学.
心理学心理学心理学
语言学的语言学.

背景情况:

患有自闭症谱系障碍 (ASD) 的人在比喻语言理解方面遇到挑战.
之前的神经成像研究表明,在语言任务期间,ASD患者的脑激活不同,但具体的神经模式尚不清楚.

研究的目的:

在使用元分析的比喻语言理解过程中识别ASD中一致的大脑激活模式.
阐明ASD中比喻语言缺陷的神经生物学基础.

主要方法:

激活概率估计 (ALE) 功能磁共振成像 (fMRI) 研究的元分析.
在五个数据库中进行系统的文献搜索,截至2025年1月.
包括六项研究,包括95名患有自闭症的个体和98名神经类型对照 (NCs).

主要成果:

无论是ASD还是NC,都激活了共同的语言网络,包括上旋 (STG) 和右侧岛屿.
与NCs相比,ASD组在左侧STG和中椎 (MTG) 中显示出显著的低活化.
在ASD组中没有观察到显著的过度激活.

结论:

患有自闭症的人使用典型的语言网络,但在图形语言的左侧STG和MTG中表现出减少的神经招募.
这种低活化表明语义和社会语言整合的缺陷,有助于ASD的务实语言障碍.

关键词:

激活可能性估计估计.自闭症谱系障碍自闭症谱系障碍图形语言理解理解能力功能性磁共振成像技术功能性磁共振成像技术神经成像是一种神经成像.

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