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与代谢功能障碍相关的脂肪性肝病和2型糖尿病:病理生理学,诊断和新兴的治疗策略

Mithil Gowda Suresh¹, Safia Mohamed², Harinivaas S Geetha¹

¹Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA 01608, United States.

World journal of diabetes

|February 16, 2026

概括

与代谢功能障碍相关的脂肪性肝病 (MASLD) 在2型糖尿病 (T2DM) 中很常见,增加肝脏和心脏病的风险. 新的药物和诊断方法为糖尿病患者管理这种疾病提供了希望.

科学领域:

肝病学和内分泌学.
代谢障碍代谢障碍代谢障碍
心血管健康心血管健康

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 在2型糖尿病 (T2DM) 中非常普遍.
在T2DM患者中,MASLD显著增加了晚期肝病 (纤维化,肝硬化,肝细胞癌) 和心血管死亡的风险.
病原发生涉及胰岛素耐药性,脂质不良,线粒体功能障碍,炎症和遗传学.

研究的目的:

审查有关T2DM中MASLD的流行病学,发病学,诊断和治疗方法的当前证据.
突出非侵入性诊断和新兴药物治疗的进展.
讨论准确医学和多学科护理的未来方向,以应对这种趋同的流行病.

主要方法:

叙事审查综合现有文献.
流行病学数据的分析,机械洞察力,诊断工具和治疗策略.
评估当前和新兴的药物疗法,包括具有肝脏益处的抗糖尿病药物.

主要成果:

MASLD影响大多数T2DM患者,增加严重肝脏并发症和心血管事件的风险.
非侵入性诊断工具看起来有前途,但在糖尿病人群中存在局限性.
几种抗糖尿病药物 (GLP-1 RAs,SGLT-2 抑制剂,皮奥格利塔) 显示出超出血糖控制的肝脏显著益处.

结论:

MASLD是T2DM中关键的并发症,需要综合管理.
新兴的药物治疗和改进的诊断正在改变MASLD治疗T2DM.
精准医学和多学科护理对于解决T2DM中MASLD日益增长的负担至关重要.

关键词:

脂肪肝是一种脂肪肝.葡萄糖样-1受体激动剂的葡萄糖样-1受体激动剂肝脏纤维化肝脏纤维化胰岛素耐药性胰岛素耐药性是一种与代谢相关的脂肪肝炎.与代谢功能障碍相关的脂肪性肝病.非侵入性诊断是一种非侵入性诊断.个性化医疗是个性化的医疗.-葡萄糖共传输体-2 抑制剂 2型糖尿病是什么? 2型糖尿病是什么?

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