尼奥米辛和克洛特里马荷载基托桑基电伤口包裹:发展,特征和抗菌性质
Sahasra Rahul Piyadigama1, Induni W Siriwardane1,2, Kalpa W Samarakoon3
1Department of Applied Computing, Faculty of Computing and Technology, University of Kelaniya, Kandy Road, Dalugama, Kelaniya 11600, Sri Lanka.
ACS omega
|February 16, 2026
概括
这项研究开发了一种新型的双抗微生物伤口包裹,使用聚乙烯醇和奇托桑治疗慢性伤口感染. 带释放neomycin和clotrimazole,具有量身定制的动力学,显示出显著的抗菌和抗真菌活性.
科学领域:
- 生物材料科学 生物材料科学
- 药物运输 药物运输 药物运输
- 传染性疾病 传染性疾病
背景情况:
- 慢性伤口经常患有多微生物感染,使愈合复杂并增加医疗负担.
- 目前的单一药物治疗对于慢性伤口中复杂的细菌和真菌感染是不够的.
研究的目的:
- 为了制造和描述一种用于慢性伤口治疗的新型双抗菌电伤口带.
- 为了评估neomycin和clotrimazole从聚乙烯醇/基托桑矩阵的受控释放动力学和抗菌疗效.
主要方法:
- 用neomycin和clotrimazole装载的电聚乙醇/奇托桑纳米纤维的制造.
- 评估机械性能,液体吸收和药物释放动力学 (韦布尔和希古奇模型).
- 使用区域抑制试验评估抗微生物活性对抗格拉姆阳性/阴性细菌和真菌 (Aspergillus niger,Lasiodiplodia theobromae).
主要成果:
- 实现了优化PVA/CS比率 (4:1) 和药物度 (0.5%尼奥米辛,1%克洛特里马).
- 含有药物的纳米纤维具有适当的机械强度 (7.49 MPa) 和高吸水率 (299%).
- 尼奥米显示出快速释放 (1小时内释放40%),而克洛特里马显示出持续释放.
- 显著的抑制区域显示出强大的抗菌 (22.5毫米与G+,18.5毫米与G-) 和抗真菌 (35.8毫米与A. niger,27.0毫米与L. theobromae) 活性.
结论:
- 成功制造了一种具有量身定制的释放型号的新型双抗菌电伤口带.
- 包裹有效地减轻多微生物感染,为慢性伤口治疗提供了一种综合方法.
- 需要进一步的体内研究和临床试验来证实安全性和有效性.
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