准备和表征含有阴离子抗菌体WSKK11和WSRR11的体
Santi Phosri1, Sukanya Tastub2, Kantaporn Kheawfu3
1Department of Chemical Engineering, Faculty of Engineering, Burapha University, Chonburi 20131, Thailand.
ACS omega
|February 16, 2026
概括
体有效地提供了用于治疗的抗微生物. 这些囊泡显示出高封装效率和低细胞毒性,证明了它们作为新型药物递送系统的潜力.
科学领域:
- 制药科学 制药科学
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
背景情况:
- 抗微生物 (AMP) 显示出治疗细菌感染的前景,但有效的输送至关重要.
- 阴体囊泡提供了一个潜在的纳米载体系统,可以增强AMP的稳定性和有针对性的输送.
- 常常是由细菌引起的,需要新的治疗策略.
研究的目的:
- 拟定和描述封装抗菌WSKK11和WSRR11的阴体囊泡.
- 为了评估封装效率,粒子特性和体的稳定性.
- 评估体封装的抗微生物和细胞毒性活性,用于潜在的治疗.
主要方法:
- 使用薄膜水化和逆相蒸发方法制备了阴体囊泡.
- 使用高性能液态染色学 (HPLC) 量化封装效率.
- 粒子大小,泽塔潜力,形态 (TEM,SEM) 和里埃变换红外光谱 (FTIR) 用于表征.
主要成果:
- 这两种配方方法都实现了WSKK11 (83.93-88.72%) 和WSRR11 (88.58-89.36%) 的高封装效率.
- 体体表现出球形形态,颗粒大小在0.75-2.02微米之间,并具有不同的泽塔电位.
- 对人类角质细胞 (HaCaT) 和纤维细胞 (MRC-5) 细胞系观察到低细胞毒性.
结论:
- 体是抗菌WSKK11和WSRR11.11的有效输送载体.
- 开发的体配方显示出治疗引起的细菌的潜力,这是由于其高封装度和低细胞毒性.
- 这项研究为皮肤病学应用的抗微生物输送中体提供了原则证明.
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