特兰胺酸治疗急性上呼吸道感染相关的喉痛:一项随机对照试验
Naoto Ishimaru1,2, Toshio Shimokawa3, Masataka Ono1
1Department of General Internal Medicine Akashi Medical Center Akashi Japan.
Journal of general and family medicine
|February 16, 2026
概括
在一项临床试验中,素酸 (TXA) 没有显著缓解上呼吸道感染引起的喉疼痛. 这项研究发现,TXA对与URTI相关的喉疼痛不适没有比安慰剂更有效.
科学领域:
- 临床医学 临床医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 特兰胺酸 (TXA) 有时用于缓解急性上呼吸道感染 (URTI) 的喉痛.
- 缺乏强有力的临床证据支持TXA对URTI喉疼痛的疗效.
研究的目的:
- 为了评估与安慰剂相比,胺酸 (TXA) 在缓解与急性URTI相关的喉疼痛方面的临床有效性.
- 用视觉模拟尺度 (VAS) 评估TXA对喉疼痛严重性的影响.
主要方法:
- 这是一项随机,双盲,安慰剂对照试验,涉及34名患有尿路感染和喉疼痛的患者 (18-65岁).
- 参与者接受了50%TXA的1g或乳糖安慰剂的1g.
- 主要结局是2小时内出现中度至重度喉痛的患者比例的变化;次要结局是VAS得分的变化.
主要成果:
- 在TXA和安慰剂组之间,没有观察到中度或更大的喉疼痛影响的患者比例 (41.2%与47.1%,p=1.00) 的显著差异.
- 在30分钟内喉疼痛VAS得分的平均变化在两组之间没有显著差异 (TXA17.3与安慰剂13.1,p=0.49).
- 在这两组中都没有报告任何不良副作用.
结论:
- 特兰胺酸 (TXA) 在缓解急性URTI相关的喉疼痛方面没有比安慰剂显著的益处.
- 可能需要进一步的研究来探索URTI喉疼痛的潜在替代治疗方法.
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