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齐申万通过抑制脂肪组织中的p21表达来减少小鼠的肥胖

You Wu^1,2,3, Huizhao Qin^1,2,4, Zhiwei Qi^1,2

¹Key Laboratory of Health Cultivation of the Ministry of Education, Beijing University of Chinese Medicine, Beijing, 102488, China.

Journal of traditional and complementary medicine

|February 16, 2026

概括

在肥胖小鼠中,ZishenWan (ZSW) 通过激活PI3K/AKT通路来降低体重并改善代谢健康. 这种传统中医药增强了脂肪细胞的亡和发热,为与肥胖有关的疾病提供了潜在的治疗策略.

科学领域:

代谢研究的研究.
药理学药理学是指药理学的学科.
传统中国医药传统中国医药

背景情况:

肥胖是2型糖尿病,代谢综合征和心血管疾病的重要危险因素.
脂肪细胞细胞循环调节越来越被认为是代谢功能障碍的一个因素.
传统中国医药配方ZishenWan (ZSW) 已经在治疗糖尿病和肥胖方面展现出潜力.

研究的目的:

调查ZSW重量调节效应的潜在机制.
探索ZSW对肥胖小鼠脂肪细胞生物学和代谢途径的影响.

主要方法:

口服ZSW给小鼠5周,与甲福明作为阳性对照.
监测体重,空腹血糖,胰岛素水平和血清脂质概况.
脊髓脂肪组织 (EAT) 的转录基因分析,通过qPCR,免疫组织化学和西部涂抹验证.

主要成果:

ZSW显著降低了体重和脂肪细胞缩,同时改善了胰岛素敏感性和分泌.
转录组分析表明ZSW改变了脂质代谢基因表达和抑制了p21表达.
ZSW激活了PI3K/AKT/FoxO1通路,导致p21降低,亡增加,并在EAT中增强了UCP1表达.

结论:

通过PI3K/AKT通路激活和EAT中的p21下调调节,ZSW可能改善与肥胖相关的代谢障碍.
这些作用促进脂肪细胞亡,增强热生成,减少缩,改善胰岛素敏感性.

关键词:

脂肪组织的脂肪组织.细胞亡 (apoptosis) 是一种死亡的过程.肥胖问题肥胖问题这就是ZishenWanWan的意思.在p21中,p21是什么意思?

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