在整个月经周期内,皮质和视网膜基线输液的内分泌调节
Melissa E Wright1, Ian D Driver1, Cassandra Crofts1
1School of Physics and Astronomy, Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK.
概括
卵巢激素雌激素和孕激素在月经周期期间影响大脑和眼睛的血液流动. 雌激素的增加促进了大脑和视网膜的输液,而孕激素提高了大脑的输液,这两种激素都减少了血液到达的时间.
科学领域:
- 神经内分泌学神经内分泌学
- 脑血管生理学 脑血管生理学
- 眼科医生 眼科 眼科
背景情况:
- 卵巢激素,雌激素和孕,表现出血管和神经保护作用.
- 脑血管相互作用与激素对大脑的影响有关.
- 了解这些影响在整个月经周期对妇女健康至关重要.
研究的目的:
- 研究卵巢激素对大脑和视网膜血管指标的神经内分泌影响.
- 在整个健康的月经周期中评估血管参数的变化.
- 为了将激素水平与特定的脑血管和视网膜血流量测量相关联.
主要方法:
- 26名健康的月经女性在早期的卵泡,晚期的卵泡和中期的卵泡阶段接受了成像.
- 使用3TMRI测量脑输液,动脉到达时间 (AAT),氧气提取分数 (OEF) 和脑血管氧气代谢率 (CMRO2).
- 视网膜血管密度和血液流动阻力使用光学连贯断层扫描血管学 (OCT-A) 进行评估.
主要成果:
- 增加的雌激素水平与增加的全球脑输液和降低的AAT相关.
- 孕激素的增加独立地与增强的全球脑输液和减少的AAT相关.
- 雌醇与视网膜血流阻力降低有关,特别是在位于中心的血管中.
结论:
- 循环中的雌激素可以增强大脑和视网膜的血液流动.
- 孕激素与大脑 perfusion 的增加有关.
- 这两种激素都促进了血液更快地到达大脑,这表明了潜在的神经保护途径.
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