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Updated: Feb 17, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

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使用PBPK/PD方法解释对simvastatin治疗的临床重要变异性

Wonho Kang1, Ana Carolina Conchon Costa1, Jose Ivan Marques Medeiros2

  • 1Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.

Journal of clinical pharmacology
|February 16, 2026
PubMed
概括

优化simvastatin (SV) 剂量需要考虑肝脏暴露于其活性形式,simvastatin氧酸 (SVA). 像肥胖这样的生理因素,而不仅仅是遗传,影响SVA水平和降低胆固醇.

关键词:
PBPKK PBPK 的意思是什么意思胃绕道术是指胃绕道术.西姆瓦斯塔丁氧化酸是什么

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