人类牛奶生物活性化合物和与过敏和传染相关的婴儿结果:系统性审查
Eduard Flores Ventura1,2, Daria Guseva3, Vanessa Hübert3,4
1Department of Biotechnology, Institute of Agrochemistry and Food Technology - Spanish National Research Council (IATA-CSIC), Valencia, Spain.
人母乳中的生物活性化合物,如PUFAs和HMOs,显示出预防婴儿过敏和感染的潜力. 特定的omega-3脂肪酸和免疫球蛋白可能起着保护作用,尽管需要更多的研究.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 人乳 (HM) 生物活性化合物对婴儿健康至关重要,影响免疫发育和抗病能力.
- 现有的研究表明,HM成分在预防过敏和感染方面发挥着作用,但缺乏全面的合成.
研究的目的:
- 系统地审查有关HM生物活性化合物对被诊断过敏,免疫疾病和传染病反应的影响的文献,在18岁以下的儿童中.
- 综合有关HM特定成分的证据,如多不和脂肪酸 (PUFA),人乳寡糖化物 (HMO) 和免疫球蛋白 (IgA).
主要方法:
- 按照PRISMA指南进行系统审查,搜索多个数据库 (PubMed,科学网,SCOPUS等). ) 的情况.
- 使用乔安娜·布里格斯研究所的检查清单进行质量评估.
- 对omega-3脂肪酸和亚托皮性皮肤炎的选定研究的元分析.
主要成果:
- 在HM烯酸/酸和过敏状况 (食物过敏,亚托皮炎) 之间发现了不良关联.
- 患有亚托皮肤炎的婴儿总omega-3脂肪酸,EPA和DGLA水平较低.
- 建议2'-FL,LDFH-I和IgA之间存在关联,降低了腹和GBS等感染的风险.
结论:
- HM生物活性化合物,包括PUFA,HMO和IgA抗体,可能会影响婴儿的过敏和感染结果.
- 关于阿托皮性皮肤炎中欧米茄-3脂肪酸的研究结果是探索性的,因为它具有很高的异质性.
- 需要使用多组学和纵向方法进行进一步的研究,以了解研究不足的HM组件及其免疫作用.
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