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Allergic Reactions02:06

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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Updated: Feb 17, 2026

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麦过敏 麦过敏

Feng Chen1, Yangshuhan Xu2, Kelong Ma1

  • 1College of Integrated Chinese and Western Medicine/College of Life Science, Anhui University of Chinese Medicine, Hefei, Anhui, China.

Asian Pacific journal of allergy and immunology
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麦过敏是一个越来越令人担忧的问题,特别是在无质食品中使用它. 准确的诊断至关重要,因为标准测试可能会错过关键的过敏原,需要先进的方法,如组件解决诊断.

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科学领域:

  • 食品科学 食品科学 食品科学
  • 过敏学 过敏学
  • 免疫学 免疫学 免疫学

背景情况:

  • 麦是一种无质的伪谷物,在东亚和俄罗斯很常见,但在东南亚不太常见.
  • 它在无质产品中的日益增长的全球使用引发了对麦过敏的担忧,症状从轻微到危及生命的过敏症.
  • 通过饮食摄入和职业吸入都是潜在的暴露途径.

研究的目的:

  • 为了突出麦过敏的诊断挑战.
  • 强调传统诊断方法的局限性.
  • 倡导改进的诊断策略,包括组件解决诊断.

主要方法:

  • 审查当前对麦过敏的理解.
  • 讨论传统的诊断方法及其局限性.
  • 引入组件解析诊断 (CRD) 和特定的过敏原,如Fag e 2和oleosins.

主要成果:

  • 使用水性提取物的常规诊断可能会错过脂溶性过敏原 (例如,油),导致错误的负结果.
  • 针对2S白蛋白Fag e 2的组件解决诊断显著提高了诊断特异性,在高达90%的症状患者中被IgE识别.
  • 与乳,花生和小麦的交叉反应是可能的,但需要进行个别评估.

结论:

  • 准确诊断麦过敏非常重要,因为它存在于未标记的无质食品中.
  • 需要标准化的检测协议,包括非水性提取,以及精确的诊断工具.
  • 严格避免是主要的管理策略,因为目前没有批准的免疫疗法.