在健康的老年人中,基于血清骨循环标记的生物变异的个性化参考间隔
Ye Qin1, Lei Zhao1, Runqing Mu1
1Department of Laboratory Medicine, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, China Medical University, Shenyang, P.R. China.
Clinical chemistry and laboratory medicine
|February 16, 2026
概括
针对老年人骨循环标记物的个性化参考间隔 (prRI) 改善了骨质疏松症的管理. 这项研究为BTMs建立了基于生物变异的prRI,比基于人口的间隔提供了更好的临床解释.
科学领域:
- 老年学是指老年学的学科.
- 生物化学 生物化学
- 临床化学 临床化学
背景情况:
- 老年人骨质疏松症的治疗依赖于血清骨循环标记 (BTMs).
- 目前的临床实用性受到基于生物变异 (BV) 的个性化参考间隔 (prRI) 缺乏限制.
研究的目的:
- 在健康的老年人中为血清骨循环标记物 (BTMs) 建立基于生物变异的个性化参考间隔 (prRI).
- 评估这些prRI在骨质疏松症管理中的临床实用性.
主要方法:
- 一项纵向研究追踪了40名健康老年参与者 (60-75岁) 的每月血清BTM (β-CTX,PINP,OC,PTH,25(OH) D) 超过6个月.
- 在人体内 (CVI),人与人之间 (CVG) 和人与人之间 (CVP) 计算的生物变异,以及分析变异 (CVA) 和参考变化值 (RCV).
- 使用这些BV参数建立prRI.
主要成果:
- 在老年人中观察到BTM的生物变异显著的个体间变化 (CVI,CVP,CVG).
- 对于PINP,OC和25(OH) D基线度,观察到性别差异,但BV参数没有.
- 基于CVI的prRI范围比基于人口的参考间隔 (popRI) 更窄,而基于CVP的prRI在个人中突出显著的异质性.
结论:
- 在老年人中,成功地建立了基于生物变异的BTMprRI.
- 与popRI相比,这些prRI提供了更具临床相关性的个人数据解释.
- 这些发现有助于在老年骨质疏松症管理方面做出更准确的临床决策.
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