在有症状的初级保健患者中,FOB Gold的诊断性能
Alan Cheung1, Steven John McCann2
1Clinical BiochemistryStockport NHS Foundation Trust.
Annals of clinical biochemistry
|February 16, 2026
概括
便免疫化学测试 (FIT) 有助于检测症状患者的结直肠癌 (CRC) 风险. 在10μg/g的值下,FOB Gold®的诊断性能与其他FIT系统在CRC检测方面具有可比性.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 临床诊断 临床诊断 临床诊断
背景情况:
- 便免疫化学测试 (FIT) 用于检测便中的血红蛋白 (f-Hb) 对于症状初级保健患者的结肠直肠癌 (CRC) 风险评估.
- FIT有助于对患者进行选,指导进一步诊断程序的决策.
研究的目的:
- 评估FOB Gold® FIT试验在症状初级保健患者中识别结肠直肠癌 (CRC) 的诊断准确性.
- 评估FOB Gold®在特定切断级别的CRC检测性能.
主要方法:
- 在2023年6月至2024年6月期间,FOB Gold® FIT对症状患者进行.
- 通过将FIT结果 (≥10μg/g被认为是阳性) 与来自Somerset癌症登记册的CRC诊断相关联,以确定诊断准确度.
- 总共有12,640名患者被纳入,并分析了随访数据.
主要成果:
- 该研究包括12,640名患者,发现了98例CRC病例.
- 在10μg/g的截止值下,FOB Gold®显示CRC检测的灵敏度为90.8%,特异性为88.9%.
- 负预测值高达99.9%,表明排除CRC的可靠性很强.
结论:
- FOB Gold®的诊断性能与其他FIT系统在有症状的初级保健患者中检测CRC的诊断性能相当.
- 10μg/g的切线为CRC查中的风险分层提供了一个可靠的值.
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