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在未经治疗的新血管AMD中,在加载阶段的抗VEGF治疗后,广场冠状腺厚度的变化

Yosuke Fukuda¹, Shoji Notomi², Satomi Shiose¹

¹Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

|February 16, 2026

概括

针对新血管与年龄相关的黄斑变性 (nAMD) 的抗VEGF治疗方法可以在中心和外围减少胸膜厚度. 在未接受过治疗的nAMD患者中,阿弗利伯塞普特的中心减少比法里西马布更大.

科学领域:

眼科医生眼科眼科
视网膜疾病视网膜疾病
药理疗法药理疗法药理疗法

背景情况:

抗血管内皮生长因子 (抗VEGF) 治疗是新血管与年龄相关的黄斑变性 (nAMD) 的标准.
虽然已知中枢胆膜变薄,但对外围变化的理解较少.
内阿弗利塞普特和法里西马布是常见的nAMD治疗方法.

研究的目的:

为了比较治疗前的nAMD患者每月三次静脉内注射aflibercept和faricimab后中央和外围斑块的胸膜厚度变化.
调查这些抗VEGF药物对外周胆道形态学的影响.

主要方法:

对142名未经治疗的nAMD患者进行前性研究,每月接受三次静脉内注射.
广场扫描源光学连贯性断层扫描 (OCT) 用于区域胆道厚度测量.
根据性别,年龄,视敏度,轴长度和nAMD亚型进行1:1的倾向分数匹配.

主要成果:

无论是aflibercept还是faricimab,都显著降低了中央和外围的胸膜厚度.
在中部3毫米子场中观察到的最实质性的减少.
与法里西马布相比,阿弗利塞普特在匹配后显著减少了中部子场胆道厚度.

结论:

无论是aflibercept还是faricimab,都会在斑点上影响胆道体厚度.
在评估抗VEGF疗效时,应与中心变化一起考虑外周胆道变化.
在nAMD中,阿弗利伯塞普可能会比法里西马布更明显地诱导中枢胆道细化.

关键词:

血管新生素-2 的使用.抗血管内皮生长因子抗血管内皮生长因子神经血管与年龄相关的黄斑变性.倾向性得分匹配的匹配方法广场光学连贯性断层扫描仪

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