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Nrf2-依赖的氧化还原调节保护神经质细胞免受聚乙烯纳米塑料诱导的过早衰老

Chae Rin Jung^1,2, EunJin Bang^1,3, Gi-Young Kim⁴

¹Basic Research Laboratory for the Regulation of Microplastic-Mediated Diseases, Dong-eui University, Busan, 47227, Republic of Korea.

Genes & genomics

|February 16, 2026

概括

聚烯纳米塑料诱导肌肉细胞过早衰老. 作为Nrf2激活剂的硫福拉通过增强抗氧化防御和维护线粒体健康来保护,突出Nrf2的作用.

科学领域:

环境健康环境健康
细胞生物学细胞生物学
毒理学毒理学毒理学

背景情况:

纳米塑料 (NP) 是新兴的环境污染物.
骨肌肉是NP暴露的目标,导致细胞过早衰老.
Nrf2途径在NP诱导的肌细胞衰老中的作用尚不清楚.

研究的目的:

为了研究Nrf2是否调节C2C12神经细胞中聚乙烯纳米塑料 (PS-NP) 诱导的衰老.
确定Nrf2激活剂硫福拉是否可以防止PS-NP诱导的衰老.

主要方法:

在C2C12神经细胞中暴露于PS-NPs以诱导衰老.
使用硫甲治疗来评估其通过Nrf2激活的保护作用.
进行了Nrf2敲击,以评估其在PS-NP诱导的衰老中的作用.

主要成果:

暴露于PS-NP降低了Nrf2活性,而硫福拉恢复了Nrf2活性,并提高了血红素氧酶-1的调节.
甲减弱了PS-NP诱导的衰老标志物和分泌表型.
硫甲保留了线粒体功能,并降低了活性氧物种 (ROS) 水平.

结论:

苏尔福拉激活Nrf2,通过氧化还原调节减轻PS-NP诱导的肌细胞过早衰老.
抗氧化剂防御途径对于保护骨肌肉免受纳米塑料毒性至关重要.

关键词:

细胞衰老细胞衰老肌囊细胞 (Myoblasts) 是一个细胞.纳米塑料是如何使用的 Nrf2 没有任何问题.硫甲是一种硫甲.

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