脊侧前额叶皮质作为潜在的电刺激目标,用于治疗前庭性恶心
Brendan McCarthy1,2,3, Erin J Howden1,2, Vaughan G Macefield2,3
1Cardiometabolic Health and Exercise Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
The Journal of physiology
|February 16, 2026
概括
脊侧前额叶皮层 (dlPFC) 的跨电刺激显示出治疗前体障碍和运动恶心的前途. 针对dlPFC可能为恶心和头提供新的治疗途径.
科学领域:
- 神经科学是一个神经科学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 精神病学是一个精神病学.
背景情况:
- 背侧前额皮质 (dlPFC) 是一个关键的大脑区域,是精神疾病中神经调节的目标.
- dlPFC具有广泛的相互连接,包括与前置系统重叠,这对平衡和恶心至关重要.
- 静脉管疾病往往缺乏有效的治疗计划,突出需要新的治疗策略.
研究的目的:
- 审查前体系统,它在恶心中的作用,以及相关的皮质处理网络.
- 探索利用穿体刺激针对前体障碍和运动病的dlPFC向的潜力.
- 讨论dlPFC刺激对恐惧性姿势和化疗诱导的恶心等疾病的治疗影响.
主要方法:
- 对dlPFC刺激和前置系统相互作用的现有文献的综述.
- 在dlPFC上使用跨交替电流刺激 (tACS) 和跨直流刺激 (tDCS) 的研究分析.
- 检查dlPFC刺激对前庭刺激引起的恶心和头的影响.
主要成果:
- 通过对dlPFC进行的跨交替电流刺激,抑制了由阴侧状状前庭刺激诱导的恶心和运动感知.
- 经直流刺激dlPFC可以减少恐惧性姿势的患者的头.
- 有证据表明dlPFC刺激和前庭处理之间存在相互作用.
结论:
- dlPFC是通过穿刺激来治疗各种前庭相关疾病的潜在治疗标.
- dlPFC神经调节在减少前体障碍和运动恶心症状方面表现出有效性.
- 未来的研究可以探索dlPFC刺激用于化疗诱导的恶心和吐.
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