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后COVID-19腹腔失调并不是由于双门屏障功能的损害
消化不良症状,包括表胃疼痛,在2019年冠状病毒疾病 (COVID-19) 后加剧. 然而,十二指管屏障功能受损或炎症并不能解释这些COVID-19后的消化问题.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 患有2019年冠状病毒病 (COVID-19) 的患者经常出现腹.
- 导致COVID-19后消化不良的潜在机制尚不清楚.
- 这项研究调查了消化不良症状与十二指甲状腺屏障功能或炎症之间的潜在联系.
研究的目的:
- 分析COVID-19感染期间和之后消化不良症状的变化.
- 确定十二指甲上皮屏障功能受损是否与COVID-19后的消化不良有关.
- 评估局部炎症功能障碍在COVID-19后腹症状中的作用.
主要方法:
- 55名COVID-19患者在住院期间和出院6个月后使用罗马III问卷评估消化不良症状.
- 对23名康复患者进行了十二指肠活检的上部内镜检查,以评估表皮屏障功能和炎症性细胞因子度.
- 在COVID-19后的患者 (有或没有消化不良) 和健康对照者之间进行了比较.
主要成果:
- 与住院期间相比,COVID-19后食后和胃上疼痛/灼热的强度显著增加 (p=0.009).
- 在COVID-19期间和后期间的消化不良症状频率中没有发现显著差异.
- 在COVID-19后的患者和健康对照人群中,双胞胎上皮屏障功能 (跨皮电阻,透性) 和促炎细胞因子度没有显著差异.
结论:
- 消化不良症状的强度,特别是腹上疼痛,在COVID-19后的时期是升高的.
- 十二指甲上皮屏障功能受损似乎不是导致这些COVID-19后消化不良症状的因素.
- 局部炎症功能障碍似乎也不能解释COVID-19后消化不良症状强度的增加.
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