相关实验视频

Updated: Feb 18, 2026

A Modified QuEChERS-HPLC Method for Detection of Polycyclic Aromatic Hydrocarbons in Zebrafish Embryos Exposed to Fine Particulate Matter

A Modified QuEChERS-HPLC Method for Detection of Polycyclic Aromatic Hydrocarbons in Zebrafish Embryos Exposed to Fine Particulate Matter

Published on: June 13, 2025

在怀孕期间分析尿道环境化学物质度的考虑因素

Danielle R Stevens^1,2, Kaleigh Hinton^1,3, Katie M O'Brien¹

¹Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina, USA.

Epidemiology (Cambridge, Mass.)

|February 16, 2026

概括

怀孕期间的水分指标在整个妊娠期间都会发生变化,但标准化尿路化学生物标志物的常见方法仍然很强大. 这些发现支持在孕妇人群中可靠的暴露评估.

科学领域:

环境健康科学环境健康科学
生殖流行病学生殖流行病学
生物标记分析生物标记分析

背景情况:

怀孕期间的生理变化可以改变水分状态.
准确的水分评估对于使用尿路生物标志物的暴露研究至关重要.
水分的变化可能会影响化学生物标志物度的解释.

研究的目的:

为了描述怀孕期间的水化轨迹.
评估不同标准化方法对尿路化学生物标志物度的影响.
评估预测水分和化学生物标志物水平在潜在的怀孕队列中的预测因素.

主要方法:

前性队列研究 (n=303) 包含从怀孕12周到38周的8次访问.
使用尿液流量率 (UFR) 和特定重量 (SG) 评估水分.
分析了mono-n-butyl甲酸盐 (MBP) 度,非标准化和标准化由UFR,SG (Boeniger) 和对共变量进行调整的SG (O'Brien).

主要成果:

具体重量线性下降,而UFR随着妊娠进展而非线性变化.
人口因素,包括种族和民族,影响了UFR和SG.
标准化方法对MBP表现出良好的一致性,而基于UFR的标准化与基于SG的方法相比,表现出较低的一致性.

结论:

尽管有系统的水化变化,但对于尿路生物标志物的常见标准化方法是强大的.
水解指标和标准化方法对生物标志物度分析的影响最小.
这些发现支持怀孕期研究中暴露评估的可靠性,无论水分的变化如何.

关键词:

生物标志物生物标志物环境健康环境健康单-n-丁甲酸甲酸盐的使用方法怀孕怀孕怀孕怀孕特定的重力是特定的重力.收集尿液样本收集尿液样本

更多相关视频

A Simple Method for Automated Solid Phase Extraction of Water Samples for Immunological Analysis of Small Pollutants

A Simple Method for Automated Solid Phase Extraction of Water Samples for Immunological Analysis of Small Pollutants

Published on: January 1, 2016

Use of a Battery of Chemical and Ecotoxicological Methods for the Assessment of the Efficacy of Wastewater Treatment Processes to Remove Estrogenic Potency

Use of a Battery of Chemical and Ecotoxicological Methods for the Assessment of the Efficacy of Wastewater Treatment Processes to Remove Estrogenic Potency

Published on: September 11, 2016

相关概念视频

Urine Studies I: Urinalysis

Urine Studies I: Urinalysis

Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...

Urine Studies II: Urine Culture and Sensitivity Test

Urine Studies II: Urine Culture and Sensitivity Test

A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...

Types of Toxins

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...