基于甲基默卡普坦抑制的天然产品对抗质症活性的评估
Bok Hee Woo1, Doyeon Kim2, Jin-Yi Hyeon1
1School of Dentistry, Pusan National University, Department of Oral Pathology, Pusan National University School of Dentistry, Yangsan, Korea., Yangsan, 50612, Korea (the Republic of).
Journal of breath research
|February 16, 2026
概括
这项研究选了252种植物提取物,以寻找口臭 (口腔恶臭) 的天然替代品. 四种特定的草本提取物显示出强大的抗菌和抗炎性质,有效地减少甲基默卡普坦的产量,以获得更安全的口腔卫生溶液.
科学领域:
- 口腔微生物学 口腔微生物学
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 炎或口腔恶臭主要是由无氧细菌产生的挥发性硫化合物 (VSC) 引起的.
- 传统的治疗方法有不良影响,需要更安全,更自然的替代方案.
研究的目的:
- 为了识别具有抗炎,抗菌和抗炎活性的植物衍生药物.
- 评估这些药物在口腔细胞上的细胞毒性.
主要方法:
- 对252种药用植物提取物进行了生物活性选.
- 评估了对P. gingivalis和F. nucleatum的抗菌作用.
- 测量了口腔细胞中抗炎活性和细胞毒性的氧化抑制.
- 通过测量使用口服Chroma.使用甲基默卡普坦抑制来确定抗哈利托斯作用.
主要成果:
- 32种提取物显示出显著的抗菌活性,VSC抑制和低细胞毒性.
- 多边形的Cuspidati Radix,Rhei Rhizoma,Pini Ramulus和Piperis Longi Fructus都显示出强大的甲基默卡普坦抑制作用.
- 组合治疗在较低度下是有效的.
结论:
- 精选的草本提取物显示出作为有效,安全和可访问的抗炎剂的潜力.
- 双重抗菌和抗炎作用支持它们在口腔卫生配方中的使用.
- 这些天然剂为口臭预防和管理提供了替代方案.
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