在进行前列腺特异性膜抗原PET/CT导向救援放射治疗后的五年结果根源性前列腺切除术

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John Nikitas^1,2, Clayton P Smith¹, Wesley R Armstrong³

¹1Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA.

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|February 16, 2026

概括

在急性前列腺切除术 (RP) 后接受救援放射治疗 (sRT) 的前列腺癌患者在以前列腺特异性膜抗原 (PSMA) PET/CT为指导的管理时表现出有利的结果. 这种成像技术可以更好地检测复发性疾病,帮助治疗决策.

科学领域:

在瘤学瘤学.
辐射疗法辐射疗法
核医学是一种核医学.

背景情况:

救援放射疗法 (sRT) 是前列腺癌复发后激进前列腺切除术 (RP) 的标准.
前列腺特异性膜抗原 (PSMA) PET/CT增强了复发前列腺癌的检测.
评估PSMA PET/CT对sRT后临床结果的影响至关重要.

研究的目的:

评估PSMA PET/CT指导管理在治疗复发前列腺癌的sRT患者的临床结果.
确定PSMA PET/CT成像对无进展生存 (PFS),无远程进展和整体生存 (OS) 的影响.

主要方法:

五项前性PSMA PET/CT研究 (2016-2021) 的回顾性分析.
包括RP后发生生化复发的患者,接受PSMA PET/CT和sRT,随访时间≥24个月.
卡普兰-梅尔和考克斯回归分析被用来评估PFS,远程进展的自由,和OS,调整临床因素.

主要成果:

113名患者符合纳入标准;中位数随访时间为59.4个月.
在PSMA PET/CT中,发现了不同阶段的复发 (TrN0M0,N1M0,M1,T0N0M0).
中位数的PFS为49.2个月;5年OS率为97.1%. 全骨盆放射治疗 (WPRT) 在TrN0M0中改善了PFS,而雄激素剥夺疗法 (ADT) 在N1/M1患者中改善了PFS.

结论:

在PSMA PET/CT引导的sRT中,与复发性前列腺癌的良好瘤结果有关.
探索性分析表明,WPRT对TrN0M0和ADT对N1/M1疾病的潜在益处.
在优化救援处理策略方面,PSMA PET/CT 具有关键作用.

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