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一种基于蛋白质的新型纤维细胞激活算法,用于评估代谢功能障碍相关的性肝病中的纤维化

Ziqi V Wang¹, Badwi B Boumelhem¹, Torsten Pennell¹

¹Liver Enzymes in Metabolism and Inflammation, Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.

Journal of gastroenterology and hepatology

|February 16, 2026

概括

一个新的FAP指数诊断工具准确地识别了MASLD患者的晚期肝纤维化. 这种非侵入性方法在与FIB-4或NFS一起使用时显著减少了不确定的结果,提高了纤维化病的分期效率.

科学领域:

肝病学肝病学是一种肝病学.
生物标志物发现发现
诊断算法诊断算法

背景情况:

准确的非侵入性纤维化检测对于管理代谢功能障碍相关的脂肪性肝病 (MASLD) 是必不可少的.
循环纤维细胞激活蛋白 (cFAP) 是激活纤维细胞的标记物,被评估其诊断潜力.
开发了一种新的算法,FAP指数,用于评估MASLD患者的肝纤维化.

研究的目的:

评估FAP指数的诊断准确性,以检测MASLD中的晚期肝纤维化 (F3-F4).
评估FAP指数在与FIB-4和NAFLD纤维化得分 (NFS) 等现有非侵入性测试相结合时,在减少不确定的结果方面的有用性.

主要方法:

分析了来自第三级肝病学诊所的两个回顾性队列 (n=160培训,n=332验证).
该FAP指数是使用后勤回归来开发的,包括年龄,2型糖尿病,氨酸转胺酶和顺序cFAP水平.
使用快速,单步酶定量测量cFAP.

主要成果:

FAP指数显示了高级纤维化病的强烈诊断准确性,在培训队列中,接收器操作特征曲线 (AUROC) 下的面积为0.875,在验证队列中为0.841.
针对FAP指数的具体切断值有效排除 (低切断值:0.157) 或预测 (高切断值:0.695) 晚期纤维化.
将FAP指数与FIB-4结合起来,可以将不确定结果减少三分之一以上,而NFS则减少约70%.

结论:

FAP指数为MASLD患者肝纤维化风险分层提供了一种快速,稳健和非侵入性的方法.
其在FIB-4或NFS之后的应用显著降低了不确定结果,而不会影响负预测值,提高了诊断效率.
FAP指数是初级保健的宝贵工具,有助于有效的肝纤维化选,而不需要弹性图像.

关键词:

在FAP指数中,FAP指数是指数.在FIB-4中.纤维细胞激活蛋白质的激活蛋白质有纤维化的纤维化.非侵袭性测试试验是非侵袭性的.

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