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淋巴系统功能障碍和化学治疗后AML的认知障碍:一项新的DTI-ALPS指数研究

Peng Li¹, Ying Li¹, Yifei Zhang²

¹Department of Radiology, The Second Hospital of Dalian Medical University, Dalian, China.

Brain research bulletin

|February 16, 2026

概括

急性髓性白血病 (AML) 患者的化疗会损害淋巴功能,通过周周脉空间 (DTI-ALPS) 指数的扩散张力成像表明,并且与认知能力下降有关. 这些发现突出了化学疗法相关认知障碍的潜在神经成像生物标志物.

科学领域:

神经成像是一种神经成像.
在瘤学瘤学.
神经学神经学

背景情况:

急性髓性白血病 (AML) 治疗可能导致认知障碍.
淋巴系统功能障碍与神经系统疾病有关.

研究的目的:

在化疗后的AML患者中,使用沿周脉空间 (DTI-ALPS) 指数的扩散张力成像来评估淋巴功能.
在这个群体中探索淋巴功能和认知表现之间的关联.

主要方法:

通过使用脑磁共振成像和认知测试,评估了21名化疗后AML患者和20名健康对照.
测量的大脑脊髓液 (CSF) 容量,基底腺周血管空间 (BG-PVS) 容量,DTI-ALPS指数和血液氧气水平依赖的-CSF合.
分析了群体差异和淋巴体标记和认知得分之间的相关性.

主要成果:

化疗后的AML患者的CSF和BG-PVS体积增加,DTI-ALPS指数降低.
认知表现受损,MMSE和MoCA得分较低,ADL得分较高.
BG-PVS体积与MMSE和MoCA得分相反相关;DTI-ALPS指数与MoCA得分正相关.

结论:

化疗后的AML患者表现出淋巴系统功能障碍和认知能力下降.
淋巴功能受损可能导致AML中化疗相关的认知缺陷.
DTI-ALPS指数和BG-PVS体积是AML患者认知障碍的潜在神经成像生物标志物.

关键词:

急性骨髓性白血病 (AML) 是一种急性骨髓性白血病.认知功能认知功能在化疗后进行的化疗.淋巴系统淋巴系统磁共振成像技术磁共振成像技术

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