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头部和部状细胞癌患者衍生的与癌症相关的纤维细胞经历衰老,但在体外辐射后保留了前瘤性质

Kris T P M Raaijmakers¹, Rens H W Peters¹, Maud Beekmans¹

¹Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.

International journal of radiation oncology, biology, physics

|February 16, 2026

概括

放射治疗导致头癌中的癌症相关纤维细胞 (CAF) 变得衰老,而不是死亡. 这些衰老的CAF促进瘤生长和迁移,但可以通过像Navitoclax这样的老化药物准.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
放射治疗研究放射治疗研究

背景情况:

放射治疗 (RT) 是治疗头部和部状细胞癌 (HNSCC) 的首要治疗方法.
晚期HNSCC患者经常经历RT后的局部区域性复发,表明治疗耐药性.
瘤微环境 (TME) 中的癌症相关纤维细胞 (CAF) 与HNSCC治疗耐药性有关.

研究的目的:

为了研究人类HNSCC衍生的CAF对辐射的反应.
为了确定辐射对CAFs的功能后果.
探索针对辐射诱导的衰老CAF的潜力.

主要方法:

初级人类HNSCC衍生的CAF暴露于单剂和分成剂的RT.
进行了CAF分离组分析,以评估对HNSCC细胞增殖和迁移的影响.
用Navitoclax (ABT-263) 治疗被辐射的CAF,以评估老化药物的疗效.

主要成果:

CAFs在高达68 Gy (单) 和3x8 Gy (分离) 的RT剂量中存活下来,进入衰老而不是亡.
受辐射的CAF保持了通过其分泌体增强HNSCC细胞增殖和迁移的能力.
衰老的CAF表现出对纳维托克拉克斯 (Navitoclax) 的敏感性增加,这是一种衰老剂.

结论:

CAF在HNSCC放射治疗反应和耐药性中发挥着重要作用.
针对衰老的CAF是一种潜在的治疗策略.
将放射治疗与CAF向剂结合起来,需要对HNSCC治疗进行进一步的研究.

关键词:

与癌症相关的纤维细胞.辐射疗法辐射疗法衰老是一种老化.瘤微环境是一个微环境.

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