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COVID-19相关的大脑MRI变化和预期的长期痴呆风险:一种前门标准启发的方法

Jingxuan Wang¹, Erin L Ferguson², Ruijia Chen³

¹Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA; Department of Epidemiology, Boston University, MA, USA.

Annals of epidemiology

|February 16, 2026

概括

通过MRI检测到的微妙的大脑变化,COVID-19可能会增加痴呆风险. 这项研究使用了一种新的因果推断方法,通过这些大脑变化将COVID-19与长期痴呆风险联系起来.

科学领域:

神经科学是一个神经科学.
流行病学流行病学
医疗成像医学成像

背景情况:

由于混因素,COVID-19对痴呆风险的长期影响很难评估.
前门标准提供了一种在存在未测量的混因素的情况下进行因果推断的方法.
大脑磁共振成像 (MRI) 变化是COVID-19对认知健康影响的潜在媒介.

研究的目的:

为了估计COVID-19对长期痴呆风险的因果影响.
为了调查短期脑部MRI变化是否会调解这种痴呆风险的增加.
在这种情况下,应用前门标准来进行可靠的因果推断.

主要方法:

利用了来自37426名55岁以上没有患有痴呆症的英国生物库数据.
根据31个先前与COVID-19相关的MRI衍生变量来定义调解器.
采用混调整的考克斯比例风险模型来评估大脑变量与痴呆发病率之间的关联.

主要成果:

在4.7年的时间里,记录了112例痴呆病例.
在31个COVID-19相关的大脑MRI变量中,29个与痴呆症发病率增加相关.
COVID-19引起的大脑MRI变化与9%更高的痴呆风险相关 (HR:1.09).

结论:

以前门标准为灵感的方法可以克服混,以评估中介效应.
与COVID-19相关的结构性大脑变化适度地提高了患痴呆症的风险.
这项研究突出了COVID-19可能影响长期认知健康的潜在途径.

关键词:

在 COVID-19 疫情中,大脑磁共振成像技术痴呆症痴呆症是一种痴呆症.前门标准的标准是前门.

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