在COPD中Codonopsis Radix的药理基础:洛贝林调节Nrf2/NF-κB介导的炎症和氧化应激
Zhengjun Chen1, Qi Shi1, Chunxia Wang1
1School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
Journal of ethnopharmacology
|February 16, 2026
概括
来自Codonopsis Radix的洛贝托林 (LBT) 通过减少炎症和氧化应激,有效治疗慢性阻塞性肺病 (COPD). 它通过调节Nrf2/NF-κB信号通路来起作用,为COPD患者提供了一条新的治疗途径.
科学领域:
- 药理学和中国传统医学
- 呼吸系统医学 呼吸系统医学
- 分子生物学分子生物学
背景情况:
- 科多诺普西斯 (Codonopsis Radix,简称CR) 是一种传统的中国草药,用于治疗肺部疾病.
- 慢性阻塞性肺病 (COPD) 的发病包括炎症和氧化应激.
- 罗贝林 (LBT) 是一种CR成分,具有抗炎和抗氧化特性,但其在COPD中的作用尚不清楚.
研究的目的:
- 确定Wen Codonopsis Radix (WCR) 中用于COPD治疗的活性成分.
- 阐明LBT通过Nrf2/NF-κB信号通路缓解COPD的机制.
主要方法:
- 建立了一个CSE/LPS诱导的COPD小鼠模型和BEAS-2B细胞损伤模型.
- 使用药理动力学评估选的WCR活性分数.
- 利用UHPLC-QE-MS和网络药理学来预测活性成分和途径.
- 通过HPLC量化候选化合物,并研究了LBT在Nrf2/NF-κB通路上的机制.
主要成果:
- 乙酸乙部分的WCR减轻了COPD小鼠的肺损伤;LBT被确定为潜在的活性成分.
- 在CSE/LPS诱导的BEAS-2B细胞中,LBT显著降低了炎症和氧化应激.
- LBT调节了Nrf2/NF-κB通路,上调SOD,并降低了IL-8,TNF-α和MDA水平,减轻了COPD的进展.
结论:
- 通过激活Nrf2,抑制NF-κB信号传递,并恢复通路平衡,LBT可缓解COPD.
- 通过抗炎和抗氧化作用,LBT可改善肺损伤并延迟COPD的进展.
- 这项研究为了解WCR的"质量效果"关系提供了基础,并支持其产品开发.
关键词:
慢性慢性肺炎是一种慢性慢性肺炎,COPD是一种慢性肺炎.科多诺普西斯 (Codonopsis Radix) 是一个有根的植物.炎症性微环境是一种微环境.洛贝提奥林是什么意思 洛贝提奥林是什么意思Nrf2 / NF-κB信号通道药理动力学物质是药理动力学物质.更多相关视频
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