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通过饮用水中微量含有的 perfluoroalkyl 和 polyfluoroalkyl 物质 (PFAS) 降低了三代小鼠胚胎线粒体的功能

Yasmyn E Winstanley¹, Donna L Holland¹, Nicole O McPherson²

¹Robinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, SA, Australia.

Environmental research

|February 16, 2026

概括

饮用水中的 perfluoroalkyl 和 polyfluoroalkyl 物质 (PFAS) 的暴露会损害女性的生育能力,并对胚胎发育产生代际影响,并观察到不可逆转的线粒体损伤.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
生殖生物学生殖生物学

背景情况:

perfluoroalkyl 和 polyfluoroalkyl 物质 (PFAS) 是城市饮用水中发现的持久合成化学物质.
暴露于PFAS与女性不孕症和发育问题有关,但机制尚不清楚.

研究的目的:

研究PFAS通过饮用水暴露对小鼠卵细胞活力和早期胚胎发育的影响.
确定细胞点和基因的机制PFAS诱导的生殖毒性.

主要方法:

雌性小鼠被暴露在不同度的PFAS (5ng/L或50ng/L) 或自来水中4周或6个月.
卵巢功能,卵细胞质量,胚胎发育,胎儿体重和线粒体功能被评估了三代.
用线粒体调节化合物来评估PFAS诱导的缺陷的可逆性.

主要成果:

暴露于PFAS导致线粒体功能受损,DNA损伤,细胞数量减少和胚胎胎体重降低.
胚胎和新生儿表型在几代人 (F1和F2后代) 中持续存在,即使后代消费了清洁的水.
发现PFAS暴露引起的线粒体功能障碍是不可逆转的.

结论:

通过饮用水接触PFAS会破坏女性的生育能力,因为它会对卵细胞和胚胎的线粒体功能造成不可逆转的损害.
暴露于PFAS会对哺乳动物胚胎发育产生跨代影响.
调查结果强调需要严格的水质政策,以减轻PFAS对生殖健康的风险.

关键词:

在PFAS中,有很多方法.饮用水饮用水饮用水胚胎胚胎是一个胚胎.女性生育能力女性生育能力线粒体中的线粒体.卵子细胞卵子细胞

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